A New Generation Prothrombin Time Method for INR

A New Generation Prothrombin Time Method for INR

Prothrombin time (PT) is the leading test for monitoring oral anticoagulation therapy (OAT). We sought to determine INR taking into account only active coagulation factors FII, FVII and FX without inhibition in patient plasmas and calibrator kits.We measured PT using a combined thromboplastin reagent. The calculation was based on a new PT method, which measures active coagulation factors (F II,...

Simplified method for international normalized ratio (INR) derivation based on the prothrombin time/INR line: an international study.

BACKGROUND The need to perform local International Sensitivity Index (ISI) calibrations and in particular the requirement for a manual method for prothrombin time (PT) determination, have proved to be obstacles to application of the WHO scheme for PT standardization. METHODS We used international normalized ratio (INR) derived with a set of only 5 European Concerted Action on Anticoagulation ...

Screening INR deviation of local prothrombin time systems.

AIM To assess the reliability of local international normalised ratios (INR) using a set of three international reference preparation (IRP) certified freeze dried plasmas. METHODS 55 centres in the United Kingdom and the Republic of Ireland participated; 36 centres employed coagulometers and 19 a manual prothrombin time technique, all with the same batch of routine commercial thromboplastin. ...

A New Method for Time-Delay Compensation in Control Systems

In this paper a new method is introduced and investigated for removing the destabilizing effects of time-delay parameter in control loops. The concept of the method is taken from the knowledge concerning the dynamic behaviour of irrational transfer functions (Ir-TF), which is discussed and investigated elswhere in frequency response domain and is explained briefly here. Ir-TFs, which are we...

Monitoring oral anticoagulant therapy--INR values for the Owren prothrombin time.